For some people, using sedatives is a routine part of horse management, but others contend that they are used too often, and not necessary in most cases.For many horse owners, sedatives and calming agents are an important tool for managing their horses in difficult situations when the horse might otherwise become a danger to others – or to himself. These medications are often used in horses to deal with situations where the horse might become anxious or aggressive: trailering, using clippers, or having teeth floated, for example.